PLA2G7, phospholipase A2 group VII, 7941

N. diseases: 136; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3280315
Disease: Platelet-Activating Factor Acetylhydrolase Deficiency
Platelet-Activating Factor Acetylhydrolase Deficiency 		0.700 Biomarker disease GENOMICS_ENGLAND
CUI: C3280315
Disease: Platelet-Activating Factor Acetylhydrolase Deficiency
Platelet-Activating Factor Acetylhydrolase Deficiency 		0.700 GeneticVariation disease UNIPROT Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase. 8675689 1996
CUI: C3280315
Disease: Platelet-Activating Factor Acetylhydrolase Deficiency
Platelet-Activating Factor Acetylhydrolase Deficiency 		0.700 GeneticVariation disease UNIPROT Loss of activity of plasma platelet-activating factor acetylhydrolase due to a novel Gln281-->Arg mutation. 9245731 1997
CUI: C3280315
Disease: Platelet-Activating Factor Acetylhydrolase Deficiency
Platelet-Activating Factor Acetylhydrolase Deficiency 		0.700 GeneticVariation disease UNIPROT A mutation in plasma platelet-activating factor acetylhydrolase (Val279Phe) is a genetic risk factor for cerebral hemorrhage but not for hypertension. 9759612 1998
CUI: C3280315
Disease: Platelet-Activating Factor Acetylhydrolase Deficiency
Platelet-Activating Factor Acetylhydrolase Deficiency 		0.700 GeneticVariation disease UNIPROT Identification of the G994--> T missense in exon 9 of the plasma platelet-activating factor acetylhydrolase gene as an independent risk factor for coronary artery disease in Japanese men. 9472966 1998
CUI: C3280315
Disease: Platelet-Activating Factor Acetylhydrolase Deficiency
Platelet-Activating Factor Acetylhydrolase Deficiency 		0.700 GeneticVariation disease UNIPROT A mutation in plasma platelet-activating factor acetylhydrolase (Val279-->Phe) is a genetic risk factor for stroke. 9412624 1997
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.220 Biomarker disease RGD The metabolic cascade leading to eicosanoid precursors--desaturases, elongases, and phospholipases A2--is altered in Zucker fatty rats. 21172452 2011
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.210 Biomarker phenotype RGD The expression and localization of plasma platelet-activating factor acetylhydrolase in endotoxemic rats. 10748027 2000
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.200 Biomarker group RGD Changes in glycerophospholipid profile in experimental nephrotic syndrome. 8692015 1996
CUI: C3280315
Disease: Platelet-Activating Factor Acetylhydrolase Deficiency
Platelet-Activating Factor Acetylhydrolase Deficiency 		0.700 Biomarker disease HPO
CUI: C0004096
Disease: Asthma
Asthma 		0.430 Biomarker disease HPO
CUI: C0013595
Disease: Eczema
Eczema 		0.100 Biomarker disease HPO
CUI: C2607914
Disease: Allergic rhinitis (disorder)
Allergic rhinitis (disorder) 		0.100 Biomarker disease HPO
CUI: C4073143
Disease: Increased level of platelet-activating factor
Increased level of platelet-activating factor 		0.100 Biomarker phenotype HPO
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.500 GeneticVariation disease LHGDN Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) has been identified as a coronary heart disease (CHD) risk predictor. 12801611 2003
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.500 AlteredExpression disease LHGDN Lipoprotein-associated phospholipase A2 activity is associated with coronary artery disease and markers of oxidative stress: a case-control study. 18779277 2008
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.500 AlteredExpression disease LHGDN In the present study, seven single nucleotide polymorphisms (SNPs) in the PLA2G7 gene were genotyped in 827 patients with coronary heart disease (CHD), of which 512 were patients with myocardial infarction (MI), and 947 age- and gender-matched controls in a Chinese Han population. 19034521 2009
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.100 AlteredExpression disease LHGDN In atherogenic aortas, an imbalance between PAF-AH and transacetylase activity, as well as lyso-PAF accumulation, may lead to unregulated PAF formation and to progression of atherosclerosis. 18587071 2008
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.100 AlteredExpression disease LHGDN Adenovirus-mediated gene transfer of human platelet-activating factor-acetylhydrolase prevents injury-induced neointima formation and reduces spontaneous atherosclerosis in apolipoprotein E-deficient mice. 11369691 2001
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.100 Biomarker disease LHGDN Reduction in the extent of atherosclerosis in apolipoprotein E-deficient mice induced by electroporation-mediated transfer of the human plasma platelet-activating factor acetylhydrolase gene into skeletal muscle. 12428682 2002
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.100 AlteredExpression disease LHGDN The association of Lp-PLA2 activity with oxLDL/LDL suggests that Lp-PLA2 may be a modulating factor in the process of atherosclerosis. 16438975 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.100 AlteredExpression disease LHGDN Although V279F and I198T mutations significantly decreased the activity of Lp-PLA(2), only the promoter rs13210554 polymorphism was associated with MI. 19034521 2009
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.100 Biomarker disease LHGDN Local production of lipoprotein-associated phospholipase A2 and lysophosphatidylcholine in the coronary circulation: association with early coronary atherosclerosis and endothelial dysfunction in humans. 17502572 2007
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.100 Biomarker disease LHGDN The goal of this study was to investigate the genetic effects of PLA2G7 on coronary artery disease (CAD) risk in two large, independent datasets with CAD. 18204052 2008
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction 		0.040 GeneticVariation disease LHGDN These findings show that the 994(G--> T) mutation of plasma PAF-AH gene may be an independent risk for atherosclerotic cerebral infarction, but not for lacunar infarction. 16086290 2005